World-first*1 discovery on Memory T Cells makes slow ageing a reality
*1 Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen Cell, (2023)
memory
t cells eliminate
the root cause of skin ageing
Aged cells are the root cause of skin's cellular ageing
Senescent cells (aged cells) cause various ageing signs by emitting ageing signals, and the aggregation of cellular ageing accelerates the skin's ageing process.
Memory T Cells:
identifying, memorizing, and eliminating aged cells
Memory T Cells are named after their ability to memorize the features of cells allowing them to quickly distinguish aged cells from healthy cells. This enables them to precisely target and eliminate aged cells.
Healthy Radiant Skin from within
Memory T Cells are believed to support the healthy regeneration of skin cells and slow down the ageing process of the skin.It has also been discovered that the greater the number of Memory T Cells, the fewer the aged cells.
How Memory T Cells contribute to healthy skin regeneration
discovered
by world-leading research
with cbrc
For over 30 years, Shiseido has been conducting research on skin
immunity with CBRC*2 (The
Cutaneous Biology Research
Center), driven by the belief that the skin’s natural defenses can prevent future skin issues. *2 Cutaneous Biology Research Center (CBRC): A comprehensive center for advanced research and development in dermatology. Established in 1989 by Harvard Medical University and Massachusetts General Hospital with the support of Shiseido.
The results of collaborative research with the CBRC.
The results of skin immunity research with CBRC have received great acclaim worldwide, including those published in the journal Nature in 1993.
In 2023, it was discovered that Memory T Cells selectively eliminate aged cells in the skin, and that the protein CXCL9, produced by epidermal keratinocytes, plays a key role in recruiting these Memory T Cells to the aged cells. This groundbreaking research was published in the prestigious scientific journal Cell.
Shiseido’s discovery to boost Memory T Cells
Over 30 years of Shiseido's skin immunity research
With extensive experience in skin immunity research, leading expert and pioneer in the discovery of Memory T Cells, Hasegawa Ph.D. shares his insights.
Over 30 years of Shiseido's skin immunity research
Fermented camellia seed extract boost Memory T Cells
Shiseido has made a groundbreaking discovery as the first in the world*3 to find that Fermented Camellia Seed Extract increases the amount of Memory T Cell recruiting factor (CXCL9). This ingredient is expected to enhance the ability of Memory T Cells to eliminate aged cells.
*3 The world's first technology to promote the expression of CXCL9, an epidermal factor important for maintaining the healthy skin (a factor that attracts the immune cells CD4 CTL), by Fermented Camellia Seed Extract (according to Shiseido using a prior technological survey (2024/3))
Aged cells are the root cause of skin's cellular ageing
Senescent cells (aged cells) cause various ageing signs by emitting ageing signals, and the aggregation of cellular ageing accelerates the skin's ageing process.
Memory T Cells:
identifying, memorizing, and eliminating aged cells
Memory T Cells are named after their ability to memorize the features of cells allowing them to quickly distinguish aged cells from healthy cells. This enables them to precisely target and eliminate aged cells.
Healthy Radiant Skin from within
Memory T Cells are believed to support the healthy regeneration of skin cells and slow down the ageing process of the skin.
It has also been discovered that the greater the number of Memory T Cells, the fewer the aged cells.
Over 30 years of Shiseido's skin immunity research
With extensive experience in skin immunity research, leading expert and pioneer in the discovery of Memory T Cells, Hasegawa Ph.D. shares his insights.
Fermented camellia seed extract boost Memory T Cells
Shiseido has made a groundbreaking discovery as the first in the world *3 to find that Fermented Camellia Seed Extract increases the amount of Memory T Cell recruiting factor (CXCL9). This ingredient is expected to enhance the ability of Memory T Cells to eliminate aged cells.
*3 The world's first technology to promote the expression of CXCL9, an epidermal factor important for maintaining the healthy skin (a factor that attracts the immune cells CD4 CTL), by Fermented Camellia Seed Extract (according to Shiseido using a prior technological survey (2024/3)